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How the worlds most successful medicine was developed

A fall 2016 symposium highlighting the fusion of science, business, and policy in the development of the world's most successful medicine, Humira.

Opening Remarks

Gloria Cordes Larson, Esq.
President, Bentley University

Introduction & Panel Moderator

Fred Ledley, MD
Director of the Center for Integration of Science and Industry and Professor (Natural and Applied Sciences & Management), Bentley University

Panelists

Governor Michael Dukakis
Distinguished Professor of Political Science, Northeastern University
Governor of Massachusetts (1975-1979, 1983-1991)
1988 Democratic Nominee for President of the United States

Robert Anderson '89, Esq., LLM, MST, CPA
Former General Council BASF Bioresearch

Robert Kamen, PhD
Former President BASF Bioresearch

Wrap Up

Robert Coughlin
President & CEO, MassBio

Panelist Bios

Governor Michael Dukakis, Distinguished Professor of Political Science, Northeastern University, Governor of Massachusetts (1975-1979, 1983-1991), and 1988 Democratic Nominee for President of the United States.
Michael Stanley Dukakis was born in Brookline, Massachusetts on November 3, 1933. His parents, Panos and Euterpe (Boukis) Dukakis both emigrated from Greece to the mill cities of Lowell and Haverhill, Massachusetts before marrying and settling in the town of Brookline, just outside Boston. Dukakis graduated from Brookline High School (1951), Swarthmore College (1955), and Harvard Law School (1960). He served for two years in the United States Army, sixteen months of which he spent with the support group to the United Nations delegation of the Military Armistice Commission in Munsan, Korea. Dukakis began his political career as an elected Town Meeting Member in the town of Brookline. He was elected chairman of his town’s Democratic organization in 1960 and won a seat in the Massachusetts Legislature in 1962. He served four terms as a legislator, winning reelection by an increasing margin each time he ran. In 1970 he was the Massachusetts Democratic Party’s nominee for Lieutenant Governor and the running mate of Boston Mayor Kevin White in the year’s gubernatorial race which they lost to Republicans Frank Sargent and Donald Dwight.

Dukakis won his party’s nomination for Governor in 1974 and beat Sargent decisively in November of that year. He inherited a record deficit and record high unemployment and is generally credited with digging Massachusetts out of one of its worst financial and economic crises in history. But the effort took its toll, and Dukakis was defeated in the Democratic primary in 1978 by Edward King. Dukakis came back to defeat King in 1982 and was reelected to an unprecedented third four-year term in 1986 by one of the largest margins in history. In 1986, his colleagues in the National Governors’ Association voted him the most effective governor in the nation.

Dukakis won the Democratic nomination for the presidency of the United States in 1988 but was defeated by George Bush. Soon thereafter, he announced that he would not be a candidate for reelection as governor. After leaving office in January 1991, Dukakis and his wife, Kitty, spent three months at the University of Hawaii where Dukakis was a visiting professor in the Department of Political Science and the School of Public Health. While at the University of Hawaii, he taught courses in political leadership and health policy and led a series of public forums on the reform of the nation’s health-care system. There has been increasing public interest in Hawaii’s first-in-the-nation universal health insurance system and the lessons that can be learned from it as the nation debates the future of health care in America. Since June 1991, Dukakis has been a Distinguished Professor of Political Science at Northeastern University and Visiting Professor at the School of Public Policy at UCLA. His research has focused on national health care policy reform and the lessons that national policy makers can learn from state reform efforts. Recently, he and former U.S. Senator Paul Simon authored a book entitled How to Get Into Politics-and Why which is designed to encourage young people to think seriously about politics and public service as a career.

Dukakis was nominated by President Clinton for a five-year term as a member of the Board of Directors of Amtrak, The National Railroad Passenger Corporation on May 21, 1998 and was confirmed by the Senate on June 25, 1998. He served a full five-year term on the Amtrak Board as Vice-Chairman. Mike and Kitty Dukakis have three children: John, Andrea, and Kara, and are the proud grandparents of seven grandchildren.

Robert Anderson '89, Esq., LLM, MST, CPA
Bob Anderson has more than 25 years of experience in the field of biotechnology. His efforts were focused on acquiring or licensing strategic intellectual property rights and providing finance and legal support in researching, developing and commercializing novel therapeutics. His experience includes guiding innovative therapeutic products from concept to commercialization both in-house and as a partner in a biotech law firm.

With Abbott Bioresearch and Abbott Laboratories (now AbbVie), Bob was a key player in acquiring, protecting and enhancing AbbVie’s’ impressive pharmaceutical product pipeline. He provided key legal support to the entire field of pharmaceuticals with a primary focus on the research, development, manufacturing and commercialization of biologic therapeutics, including AbbVie’s flagship pharmaceutical - HUMIRA®. HUMIRA® is the first fully human therapeutic antibody which has received regulatory approval in an exceptional number of indications.

Bob formerly served as General Counsel for BASF Bioresearch Corporation (BBC). He was a founding member of BASF Bioresearch Corporate’s management team, which built a world-class research, development and biologics manufacturing organization from 10 employees up to a current staff of approximately 1,000 scientists, clinicians, engineers and professional staff (Currently AbbVie Bioresearch). Bob was also a key member of BASF’s legal team that negotiated and executed the $6.9 billion dollar acquisition of the BASF Pharma Group by Abbott Laboratories. He then worked for over a decade for Abbott to further develop and commercialize HUMIRA® and other novel therapeutics.

Bob Anderson holds an LLM and JD from Suffolk University Law School, a Masters in Taxation from Bentley University and a BS in Accounting and Finance from Villanova University.

Robert Kamen, PhD
Bob Kamen is an Entrepreneur in Residence with Third Rock Ventures where he works on the formation and development of biologics companies. Bob has more than 30 years of leadership experience in the pharmaceutical and biotechnology industries. With Third Rock, he has played a key role in launching and building Jounce Therapeutics, a cancer immunotherapy company, and Neon Therapeutics, a company that is developing novel personalized cancer immunotherapies based on tumor neoantigen biology. He serves on the board of directors of both companies.

Beyond his Third Rock activities, Bob serves on the boards of biotech companies including Harbour Antibodies BV, Lycera Corporation, and Epimab Biotherapeutics. He also advises other biopharmaceutical firms.

Bob was formerly president of Abbott Bioresearch Center in Worcester, where he oversaw the discovery and production of Humira®, the first fully human antibody product to achieve marketing approval, which has become a life-changing medicine for a great many patients with a wide variety of autoimmune diseases. Humira has been the world’s top selling pharmaceutical for many years. Bob was also a member of the Abbott Pharmaceuticals Executive Management Committee. He had been the president of BASF Bioresearch Corporation for ten years, until Abbott Laboratories acquired it in 2001. After retiring from Abbott, he was chairman and co-founder of BioAssets Development Corp., a biotherapeutics company focused on spinal diseases, which was acquired by Cephalon. Earlier in his career, during the 1980s, he led discovery at the pioneering Cambridge biotech company Genetics Institute Inc., subsequently acquired by Wyeth Pharmaceuticals.

Bob holds an A.B. in biophysics from Amherst College and a Ph.D. in biochemistry and molecular biology from Harvard University. During his academic scientific career he worked on the molecular biology of DNA tumor viruses at the Imperial Cancer Research Laboratories in London, UK.

Bob spends his spare time pretending to be an athlete on his road bike or walking with his best friend Chunk.

Robert Coughlin, President and CEO of MassBio
As President and CEO of the Massachusetts Biotechnology Council, Bob’s mission is to advance Massachusetts' leadership in the life sciences to grow the industry, add value to the healthcare system and improve patient lives. He is very familiar with all areas of the Massachusetts life sciences super cluster and is a passionate advocate for research and the biotechnology community.

Bob has spent his career in the public and private sectors, prior to his position at MassBio he served as the Undersecretary of Economic Development within Governor Deval Patrick's administration. Prior to that, he was elected as State Representative to the 11th Norfolk district for three terms. In the legislature both healthcare and economic development were his priorities.

In the world of business he specialized in the environmental services industry and moved on to capital management and venture capital. He has held senior executive positions in both fields.

He is a graduate of the Massachusetts Maritime Academy where he majored in Marine Engineering, and is a Lieutenant in the United States Naval Reserve.

Coughlin has also been active in the community; he is a past board member of the Massachusetts Maritime Academy and Beth Israel Deaconess Hospital. He is currently serving on the board of directors for The Schwartz Center for Compassionate Healthcare, The Boston Irish Business Association and Aridis Pharmaceuticals. He serves as the honorary chairman of the Great Strides Cystic Fibrosis Walk since 1996. In years past, he co-chaired the Children’s Hospital Boston signature event, Champions for Children’s and the Schwartz Center’s Compassionate Healthcare Dinner. In 2011, the American Diabetes Association honored Bob with their Father of the Year Award. In 2012, the Cystic Fibrosis Foundation honored Bob with the CF Foundation Volunteer Leadership Award and in 2013; he received the Boston Irish Business Award from the Boston Irish Business Association. Most recently, in 2015 the National Tay-Sachs & Allied Diseases Association honored Bob at their Imagine & Believe Gala and he received the Solas Award from the Irish International Immigrant Center.